New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells

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• 作者：Nazmiye B. Yapici ; Steffen Jockusch ; Alberto Moscatelli ; Srinivas Rao Mandalapu ; Yasuhiro Itagaki ; Dallas K. Bates ; Sherri Wiseman ; K. Michael Gibson ; Nicholas J. Turro ; Lanrong Bi
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：14
• 期：1
• 页码：50-53
• 全文大小：246K
• 年卷期：v.14,no.1(January 6, 2012)
• ISSN：1523-7052

文摘

The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (鈥H) in living cells are described. These probes are highly selective for 鈥H in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate 鈥H imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for 鈥H detection.