Carbon Nanotubes as Structural Nanofibers for Hyaluronic Acid Hydrogel Scaffolds

详细信息    查看全文

• 作者：Sanjib Bhattacharyya ; Samuel Guillot ; Hinda Dabboue ; Jean-Franç ; ois Tranchant ; Jean-Paul Salvetat
• 刊名：Biomacromolecules
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：9
• 期：2
• 页码：505 - 509
• 全文大小：1046K
• 年卷期：v.9,no.2(February 2008)
• ISSN：1526-4602

文摘

We have successfully dispersed functionalized single-walled carbon nanotubes (SWNTs) within hyaluronic acid–water solutions. Hybrid hyaluronic acid (HA) hydrogels with SWNTs were then formed by cross-linking with divinyl sulfone. We have found a considerable change in the morphology of the lyophilized hybrid hydrogels compared to HA hydrogels. The high water uptake capacity, an important property of HA hydrogels, remained almost unchanged after 2 wt % SWNT (vs HA) incorporation, despite a dramatic enhancement in the dynamic mechanical properties of the hybrid hydrogels compared to native ones. We have found a 300% enhancement in the storage modulus of hybrid hydrogel with only 2 wt % of SWNTs vs HA (0.06 wt % vs total weight including water content). This apparent contradiction can be explained by a networking effect between SWNTs, mediated by HA chains. As in biological tissue, HA plays a dual role of matrix and linker for the rigid reinforcing nanofibers.