Accurate Identification and Selective Removal of Rotavirus Using a Plasmonic鈥揗agnetic 3D Graphene Oxide Architecture
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- 作者：Zhen Fan ; Brian Yust ; Bhanu Priya Viraka Nellore ; Sudarson Sekhar Sinha ; Rajashekhar Kanchanapally ; Rebecca A. Crouch ; Avijit Pramanik ; Suhash Reddy Chavva ; Dhiraj Sardar ; Paresh Chandra Ray
- 刊名：The Journal of Physical Chemistry Letters
- 出版年：2014
- 出版时间：September 18, 2014
- 年：2014
- 卷：5
- 期：18
- 页码：3216-3221
- 全文大小：381K
- ISSN：1948-7185
文摘
According to the World Health Organization, even in the 21st century, more than one million children die each year due to the rotavirus contamination of drinking water. Therefore, accurate identification and removal of rotavirus are very important to save childrens鈥?lives. Driven by the need, in this Letter, we report for the first time highly selective identification and removal of rotavirus from infected water using a bioconjugated hybrid graphene oxide based three-dimensional (3D) solid architecture. Experimental results show that due to the presence of a high intensity of 鈥渉ot spots鈥?in the 3D network, an antibody-attached 3D plasmonic鈥搈agnetic architecture can be used for accurate identification of rotavirus using surface-enhanced Raman spectroscopy (SERS). Reported data demonstrate that the antibody-attached 3D network binds strongly with rotavirus and is capable of highly efficient removal of rotavirus, which has been confirmed by SERS, fluorescence imaging, and enzyme-linked immunosorbent assay (ELISA) data. We discuss a possible mechanism for accurate identification and efficient removal of rotavirus from infected drinking water.