Glycosylated Foldamers To Probe the Carbohydrate-Carbohydrate Interaction

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• 作者：Graham L. Simpson ; Andrew H. Gordon ; David M. Lindsay ; Netnepa Promsawan ; Matthew P. Crump ; Keith Mulholland ; Barry R. Hayter ; Timothy Gallagher
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：August 23, 2006
• 年：2006
• 卷：128
• 期：33
• 页码：10638 - 10639
• 全文大小：74K
• 年卷期：v.128,no.33(August 23, 2006)
• ISSN：1520-5126

文摘

The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate-carbohydrate interactions.