Copper-Catalyzed Domino Three-Component Approach for the Assembly of 2-Aminated Benzimidazoles and Quinazolines
详细信息 查看全文
- 作者：Lam Quang Tran ; Jihui Li ; Luc Neuville
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：June 19, 2015
- 年：2015
- 卷：80
- 期：12
- 页码：6102-6108
- 全文大小：478K
- ISSN：1520-6904
文摘
A copper-promoted three-component synthesis of 2-aminobenzimidazoles (1) or of 2-aminoquinazolines (2) involving cyanamides, arylboronic acids, and amines has been developed. The operationally simple oxidative process, performed in the presence of K2CO3, a catalytic amount of CuCl2路2H2O, 2,2鈥?bipyridine, and an O2 atmosphere (1 atm), allows the rapid assembly of either benzimidazoles or quinazolines starting from aryl- or benzyl-substituted cyanamides, respectively. In this process, the copper promotes the formation of three bonds, two C鈥揘 bonds, and an additional bond resulting from C鈥揌 functionalization event.