Zeolite Structures Loading with an Anticancer Compound As Drug Delivery Systems

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• 作者：Ricardo Amorim ; Nat谩lia Vila莽a ; Olga Martinho ; Rui M. Reis ; Mariana Sardo ; Jo茫o Rocha ; Ant贸nio M. Fonseca ; F谩tima Baltazar ; Isabel C. Neves
• 刊名：The Journal of Physical Chemistry C
• 出版年：2012
• 出版时间：December 6, 2012
• 年：2012
• 卷：116
• 期：48
• 页码：25642-25650
• 全文大小：463K
• 年卷期：v.116,no.48(December 6, 2012)
• ISSN：1932-7455

文摘

Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of 伪-cyano-4-hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, p>1p>H NMR, p>13p>C and p>27p>Al solid-state MAS NMR, and UV鈥搗is), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell death.