Tailored Silica鈥揂ntibiotic Nanoparticles: Overcoming Bacterial Resistance with Low Cytotoxicity

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• 作者：Larissa Brentano Capeletti ; Luciane Fran莽a de Oliveira ; Kaliandra de Almeida Gon莽alves ; Jessica Fernanda Affonso de Oliveira ; 脗ngela Saito ; J枚rg Kobarg ; Jo茫o Henrique Zimnoch dos Santos ; Mateus Borba Cardoso
• 刊名：Langmuir
• 出版年：2014
• 出版时间：July 1, 2014
• 年：2014
• 卷：30
• 期：25
• 页码：7456-7464
• 全文大小：413K
• ISSN：1520-5827

文摘

New and more aggressive antibiotic resistant bacteria arise at an alarming rate and represent an ever-growing challenge to global health care systems. Consequently, the development of new antimicrobial agents is required to overcome the inefficiency of conventional antibiotics and bypass treatment limitations related to these pathologies. In this study, we present a synthesis protocol, which was able to entrap tetracycline antibiotic into silica nanospheres. Bactericidal efficacy of these structures was tested against bacteria that were susceptible and resistant to antibiotics. For nonresistant bacteria, our composite had bactericidal efficiency comparable to that of free-tetracycline. On the other hand, the synthesized composites were able to avoid bacterial growth of resistant bacteria while free-tetracycline has shown no significant bactericidal effect. Finally, we have investigated the cytotoxicity of these nanoparticles against mammalian cells to check any possible poisoning effect. It was found that these nanospheres are not apoptosis-inducers and only a reduction on the cell replication rate was seen when compared to the control without nanoparticles.