Antiplasmodial Alkaloids from Desmos rostrata

详细信息    查看全文

• 作者：Ngoc Tuan Nguyen ; Van Cuong Pham ; Marc Litaudon ; Franç ; oise Gué ; ritte ; Philippe Grellier ; Van Tuyen Nguyen ; Van Hung Nguyen
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：December 26, 2008
• 年：2008
• 卷：71
• 期：12
• 页码：2057-2059
• 全文大小：110K
• 年卷期：v.71,no.12(December 26, 2008)
• ISSN：1520-6025

文摘

Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC₅₀ 2.4 μM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC₅₀ of 4.2, 1.6, and 0.9 μM, respectively).