Isolation and Identification of Antiplatelet Aggregatory Principles from the Leaves of Piper lolot

详细信息    查看全文

• 作者：Chia-Ying Li ; Wei-Jern Tsai ; Amooru Gangaiah Damu ; E-Jian Lee ; Tian-Shung Wu ; Nguyen Xuan Dung ; Tran Dinh Thang ; Le Thanh
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：November 14, 2007
• 年：2007
• 卷：55
• 期：23
• 页码：9436 - 9442
• 全文大小：142K
• 年卷期：v.55,no.23(November 14, 2007)
• ISSN：1520-5118

文摘

The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, piperlotine A–L (1–12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.