Evidence for a Trianion Intermediate in the Metalation of 4-Hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic Acid. Methodology and Application to Racemic 5,5鈥?Didesisopropyl-5,5鈥?dialkylapogossypol Derivati
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- 作者：Tin Thanh Le ; Nguyet Trang Thanh Chau ; Tai Tan Nguyen ; Josselin Brien ; Trieu Tien Thai ; Arnaud Nourry ; Anne-Sophie Castanet ; Kim Phi Phung Nguyen ; Jacques Mortier
- 刊名：Journal of Organic Chemistry
- 出版年：2011
- 出版时间：January 21, 2011
- 年：2011
- 卷：76
- 期：2
- 页码：601-608
- 全文大小：926K
- 年卷期：v.76,no.2(January 21, 2011)
- ISSN：1520-6904
文摘
The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5鈥?didesisopropyl-5,5鈥?dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins.