Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata

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• 作者：Jaeyoung Kwon ; Nguyen Tuan Hiep ; Dong-Woo Kim ; Bang Yeon Hwang ; Hak Ju Lee ; Woongchon Mar ; Dongho Lee
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1893-1901
• 全文大小：298K
• ISSN：1520-6025

文摘

Seventeen new prenylated xanthones (1鈥?b>17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18鈥?b>23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC₅₀ values of 0.7鈥?6.6 渭M.