Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications

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• 作者：Nicholas Ndiege ; Renugan Raidoo ; Michael K. Schultz ; Sarah Larsen
• 刊名：Langmuir
• 出版年：2011
• 出版时间：March 15, 2011
• 年：2011
• 卷：27
• 期：6
• 页码：2904-2909
• 全文大小：792K
• 年卷期：v.27,no.6(March 15, 2011)
• ISSN：1520-5827

文摘

Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 (⁶⁸Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile 鈥渃lickable鈥?zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.