Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator

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• 作者：Evan W. Miller ; Nicolas Taulet ; Carl S. Onak ; Elizabeth J. New ; Julie K. Lanselle ; Gillian S. Smelick ; Christopher J. Chang
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：December 8, 2010
• 年：2010
• 卷：132
• 期：48
• 页码：17071-17073
• 全文大小：174K
• 年卷期：v.132,no.48(December 8, 2010)
• ISSN：1520-5126

文摘

Hydrogen peroxide (H₂O₂) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H₂O₂ on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H₂O₂ as well as remote control of cell behavior via H₂O₂-mediated pathways.