Total Synthesis of Shishijimicin A

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• 作者：K. C. Nicolaou ; Zhaoyong Lu ; Ruofan Li ; James R. Woods ; Te-ik Sohn
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 15, 2015
• 年：2015
• 卷：137
• 期：27
• 页码：8716-8719
• 全文大小：380K
• ISSN：1520-5126

文摘

The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.