Unusual Chiroptical Properties of the Cryptophane-222 Skeleton

详细信息    查看全文

• 作者：Delphine Pitrat ; Nicolas Daugey ; Marion Jean ; Nicolas Vanthuyne ; Frank Wien ; Laurent Ducasse ; Nathalie Calin ; Thierry Buffeteau ; Thierry Brotin
• 刊名：Journal of Physical Chemistry B
• 出版年：2016
• 出版时间：December 15, 2016
• 年：2016
• 卷：120
• 期：49
• 页码：12650-12659
• 全文大小：587K
• ISSN：1520-5207

文摘

Enantiopure cryptophane-222 derivative (1) devoid of substituents was obtained via high-performance liquid chromatography (HPLC) using chiral stationary phases. The chiroptical properties of 1 were determined from polarimetry, electronic circular dichroism (ECD), synchrotron radiation circular dichroism (SRCD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) experiments and were compared to those of the cryptophane-A (2) derivative. Unusual polarimetric results were obtained for 1 in CHCl₃ solvent as the sign of the optical rotation (OR) values changes in the nonresonance region above 365 nm, whereas no change was observed in the CH₂Cl₂ solvent. ECD spectra in the ¹L_a and ¹L_b regions were very similar for the two solutions and could not explain these unusual polarimetric properties. In contrast, SRCD spectra in the ¹B_b region revealed spectral differences for the two solutions, which have been associated with conformational changes of the three linkers by time-dependent density functional theory (TDDFT) calculations. DFT calculations of the OR support that conformational changes may explain the polarimetric results obtained for the two solvents. Finally, TDDFT calculations of the ECD as well as DFT calculations of the VCD and ROA allowed the attribution of the (−)₅₈₉-PP absolute configuration for 1 in solution, as determined from the X-ray structures of 1.