Antifungal Activity of Resveratrol Derivatives against Candida Species
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- 作者：Benjamin Houill茅 ; Nicolas Papon ; Leslie Boudesocque ; Eric Bourdeaud ; S茅bastien Besseau ; Vincent Courdavault ; C茅cile Enguehard-Gueiffier ; Guillaume Delanoue ; Laurence Gu茅rin ; Jean-Philippe Bouchara ; Marc Clastre ; Nathalie Giglioli-Guivarc鈥檋 ; J茅r么me Guillard ; Arnaud Lanoue
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：July 25, 2014
- 年：2014
- 卷：77
- 期：7
- 页码：1658-1662
- 全文大小：291K
- ISSN：1520-6025
文摘
trans-Resveratrol (1a) is a phytoalexin produced by plants in response to infections by pathogens. Its potential activity against clinically relevant opportunistic fungal pathogens has previously been poorly investigated. Evaluated herein are the candidacidal activities of oligomers (2a, 3鈥?b>5) of 1a purified from Vitis vinifera grape canes and several analogues (1b鈥?b>1j) of 1a obtained through semisynthesis using methylation and acetylation. Moreover, trans-蔚-viniferin (2a), a dimer of 1a, was also subjected to methylation (2b) and acetylation (2c) under nonselective conditions. Neither the natural oligomers of 1a (2a, 3鈥?b>5) nor the derivatives of 2a were active against Candida albicans SC5314. However, the dimethoxy resveratrol derivatives 1d and 1e exhibited antifungal activity against C. albicans with minimum inhibitory concentration (MIC) values of 29鈥?7 渭g/mL and against 11 other Candida species. Compound 1e inhibited the yeast-to-hyphae morphogenetic transition of C. albicans at 14 渭g/mL.