Biofunctionalization of Anisotropic Nanocrystalline Semiconductor鈥揗agnetic Heterostructures

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• 作者：Nicoletta Depalo ; Pasquale Carrieri ; Roberto Comparelli ; Marinella Striccoli ; Angela Agostiano ; Luca Bertinetti ; Claudia Innocenti ; Claudio Sangregorio ; M. Lucia Curri
• 刊名：Langmuir
• 出版年：2011
• 出版时间：June 7, 2011
• 年：2011
• 卷：27
• 期：11
• 页码：6962-6970
• 全文大小：1004K
• 年卷期：v.27,no.11(June 7, 2011)
• ISSN：1520-5827

文摘

Asymmetric binary nanocrystals (BNCs) formed by a spherical 纬-Fe₂O₃ magnetic domain epitaxially grown onto a lateral facet of a rodlike anatase TiO₂ nanorod have been functionalized with PEG-terminated phospholipids, resulting in a micellar system that enables the BNC dispersion in aqueous solution. The further processability of the obtained water-soluble BNC including PEG lipid micelles and their use in bioconjugation experiments has been successfully demonstrated by covalently binding to bovine serum albumin (BSA). The whole process has also been preliminarily performed on spherical iron oxide nanocrystals (NCs) and TiO₂ nanorods (NRs), which form single structural units in the heterostructures. Each step has been thoroughly monitored by using optical, structural, and electrophoretic techniques. In addition, an investigation of the magnetic behavior of the iron oxide NCs and BNCs, before and after incorporation into PEG lipid micelles and subsequently bioconjugation, has been carried out, revealing that the magnetic characteristics are mostly retained. The proposed approach to achieving water-soluble anisotropic BNCs and their bioconjugates has a large potential in catalysis and biomedicine and offers key functional building blocks for biosensor applications.