Study of the Complexation of Oxacillin in 1-(4-Carbomethoxypyrrolidone)-Terminated PAMAM Dendrimers

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• 作者：Jon S. Hansen ; Mario Ficker ; Johannes F. Petersen ; Bjarne E. Nielsen ; Saira Gohar ; J酶rn B. Christensen
• 刊名：Journal of Physical Chemistry B
• 出版年：2013
• 出版时间：November 27, 2013
• 年：2013
• 卷：117
• 期：47
• 页码：14865-14874
• 全文大小：586K
• 年卷期：v.117,no.47(November 27, 2013)
• ISSN：1520-5207

文摘

The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD₃OD and CDCl₃. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K_d) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by ¹H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.