Rh- and Cu-Cocatalyzed Aerobic Oxidative Approach to Quinazolines via [4 + 2] C–H Annulation with Alkyl Azides
详细信息 查看全文
- 作者：Xiaoyang Wang ; Ning Jiao
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：May 6, 2016
- 年：2016
- 卷：18
- 期：9
- 页码：2150-2153
- 全文大小：441K
- 年卷期：0
- ISSN：1523-7052
文摘
A novel and efficient rhodium- and copper-co-catalyzed C–H bond activation and annulation for the construction of bioactively important quinazolines has been developed. This [4 + 2] annulation strategy utilizing alkyl azides as the carbon–heteroatom synthons shows high efficiency in the synthesis of six-membered benzoheterocycles containing two heteroatoms. This aerobic oxidative protocol provides a useful application of simple alkyl azides in N-heterocycle synthesis with N2 and H2O as byproducts.