Highly Enantioselective Conjugate Addition of Malononitrile to 2-Enoylpyridines with Bifunctional Organocatalyst

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• 作者：Nagaraju Molleti ; Nirmal K. Rana ; Vinod K. Singh
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4322-4325
• 全文大小：236K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

An efficient enantioselective conjugate addition of malononitrile to a range of 尾-substituted 2-enoylpyridines catalyzed by cinchona alkaloid-based bifunctional urea catalysts has been developed. Both enantiomers of the products could be achieved with the same level of enantioselectivity by using pseudoenantiomeric catalysts in up to 97% ee and in excellent yields. One of the enantioenriched products has been transformed to a highly functionalized piperidone derivative.