An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction

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• 作者：Takashi Nishikata ; Yushi Noda ; Ryo Fujimoto ; Tomomi Sakashita
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：November 6, 2013
• 年：2013
• 卷：135
• 期：44
• 页码：16372-16375
• 全文大小：308K
• 年卷期：v.135,no.44(November 6, 2013)
• ISSN：1520-5126

文摘

伪-Halocarbonyl compounds undergo 尾-hydrogen elimination to give conjugated olefins in the presence of a transition-metal catalyst. However, a copper/triamine catalyst system can induce the alkylative Mizoroki鈥揌eck reaction of styrenes with tertiary-alkyl halides possessing a withdrawing group under very mild conditions. This reaction provides an efficient synthetic methodology for tertiary-alkylated styrenes.