Oxazaborolidine-Catalyzed Enantioselective Reduction of α-Methylene Ketones to Allylic Alcohols

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• 作者：Jun-ichi Matsuo ; Takaaki Kozai ; Osamu Nishikawa ; Yu Hattori ; Hiroyuki Ishibashi
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：September 5, 2008
• 年：2008
• 卷：73
• 期：17
• 页码：6902-6904
• 全文大小：149K
• 年卷期：v.73,no.17(September 5, 2008)
• ISSN：1520-6904

文摘

Oxazaborolidine-catalyzed enantioselective reduction of α-methylene ketones was efficiently carried out by using borane−diethylaniline as a stoichiometric reducing agent. The combination of this method and subsequent hydrogenation of thus-formed allylic alcohol improved stereoselectivity in the reduction of 24-oxocholesteryl ester to 24-(R)-hydroxycholesteryl ester.