FeCl3-Catalyzed Self-Cleaving Deprotection of Methoxyphenylmethyl-Protected Alcohols

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• 作者：Yoshinari Sawama ; Masahiro Masuda ; Shota Asai ; Ryota Goto ; Saori Nagata ; Shumma Nishimura ; Yasunari Monguchi ; Hironao Sajiki
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：434-437
• 全文大小：357K
• ISSN：1523-7052

文摘

4-Methoxyphenylmethyl ethers are widely utilized as alcohol protecting groups. FeCl₃ effectively catalyzes the deprotection of methoxyphenylmethyl-type ethers in a self-cleaving manner to produce oligomeric derivatives and alcohols. Remarkably, the highly pure mother alcohols can be obtained without silica gel column chromatography by using the 2,4-dimethoxyphenylmethyl group as a protective group.