Triterpene Acids from Poria cocos and Their Anti-Tumor-Promoting Effects
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- 作者：Toshihiro Akihisa ; Yuji Nakamura ; Harukuni Tokuda ; Emiko Uchiyama ; Takashi Suzuki ; Yumiko Kimura ; Kazuo Uchikura ; Hoyoku Nishino
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：948 - 953
- 全文大小：91K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
The structures of six new lanostane-type triterpene acids isolated from the epidermis of the sclerotia of Poria cocoswere established to be 15
-hydroxydehydrotumulosic acid (5), 16,25-dihydroxydehydroeburicoic acid (9), 5,8-peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid H (11), 16-deoxyporicoic acid B (12), and poricoic acidCM (16) on the basis of spectroscopic methods. On evaluation of these six and 11 other known triterpene acids isolatedfrom the sclerotium, 1-4, 6-8, 13-15, and 17, against the Epstein-Barr virus early antigen (EBV-EA) activationinduced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds except for 1, 3, 4, and 8exhibited inhibitory effects with IC50 values of 195-340 mol ratio/32 pmol TPA. Compound 12 and poricoic acid C(13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
-hydroxydehydrotumulosic acid (5), 16,25-dihydroxydehydroeburicoic acid (9), 5,8-peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid H (11), 16-deoxyporicoic acid B (12), and poricoic acidCM (16) on the basis of spectroscopic methods. On evaluation of these six and 11 other known triterpene acids isolatedfrom the sclerotium, 1-4, 6-8, 13-15, and 17, against the Epstein-Barr virus early antigen (EBV-EA) activationinduced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds except for 1, 3, 4, and 8exhibited inhibitory effects with IC50 values of 195-340 mol ratio/32 pmol TPA. Compound 12 and poricoic acid C(13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.