Cristaxenicin A, an Antiprotozoal Xenicane Diterpenoid from the Deep Sea Gorgonian Acanthoprimnoa cristata

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• 作者：Shin-Taro Ishigami ; Yasuyuki Goto ; Noboru Inoue ; Shin-Ichiro Kawazu ; Yoshitsugu Matsumoto ; Yukimitsu Imahara ; Moto Tarumi ; Hiromi Nakai ; Nobuhiro Fusetani ; Yoichi Nakao
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：December 7, 2012
• 年：2012
• 卷：77
• 期：23
• 页码：10962-10966
• 全文大小：250K
• 年卷期：v.77,no.23(December 7, 2012)
• ISSN：1520-6904

文摘

A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC₅₀ values of 0.088 and 0.25 渭M, respectively.