Nahuoic Acids B–E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp. SCSGAA 0027

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• 作者：Xu-Hua Nong ; Xiao-Yong Zhang ; Xin-Ya Xu ; Jie Wang ; Shu-Hua Qi
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：January 22, 2016
• 年：2016
• 卷：79
• 期：1
• 页码：141-148
• 全文大小：415K
• ISSN：1520-6025

文摘

Four new polyol polyketides containing a decalin ring, nahuoic acids B–E (1–4), together with a known analogue, nahuoic acid A (5), possessing an unprecedented carbon skeleton, were isolated from a culture broth of the marine-derived Streptomyces sp. SCSGAA 0027. Their structures were determined by detailed analysis of spectroscopic data and chemical transformations including acetonide formation and Mosher’s ester method. Compounds 1–5 showed weak antibiofilm activity against Shewanella onedensis MR-1 biofilm. This is the first series of analogues of the novel selective SETD8 inhibitor nahuoic acid A.