An Enantioselective Route to -Methyl Carboxylic Acids via Metal and Enzyme Catalysis

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• 作者：Jakob Norinder ; Krisztiá ; n Bogá ; r ; Lisa Kanupp ; Jan-E. Bä ; ckvall
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：November 22, 2007
• 年：2007
• 卷：9
• 期：24
• 页码：5095 - 5098
• 全文大小：88K
• 年卷期：v.9,no.24(November 22, 2007)
• ISSN：1523-7052

文摘

Dynamic kinetic resolution of allylic alcohols to allylic acetates followed by copper-catalyzed allylic substitution gave alkenes in high yieldsand high optical purity. Subsequent oxidative C-C double bond cleavage afforded pharmaceutically important -methyl substituted carboxylicacids in high ee.