Iron-Catalyzed Direct Arylation through Directed C−H Bond Activation

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• 作者：Jakob Norinder ; Arimasa Matsumoto ; Naohiko Yoshikai ; Eiichi Nakamura
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：May 7, 2008
• 年：2008
• 卷：130
• 期：18
• 页码：5858 - 5859
• 全文大小：94K
• 年卷期：v.130,no.18(May 7, 2008)
• ISSN：1520-5126

文摘

An iron-catalyzed C−C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0 °C in a good to quantitative yield. The reaction involves a C−H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro-2-methylpropane, in the absence of which a very low product yield was observed.