Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes

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• 作者：Ti-Hsuan Ku ; Miao-Ping Chien ; Matthew P. Thompson ; Robert S. Sinkovits ; Norman H. Olson ; Timothy S. Baker ; Nathan C. Gianneschi
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 8, 2011
• 年：2011
• 卷：133
• 期：22
• 页码：8392-8395
• 全文大小：878K
• 年卷期：v.133,no.22(June 8, 2011)
• ISSN：1520-5126

文摘

Micelles were prepared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A, protein phosphatase-1, and matrix metalloproteinases 2 and 9. We examine reversible switching of the morphology of these micelles through a phosphorylation鈭抎ephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, the exceptional uniformity of these polymer-peptide particles makes them amenable to cryo-TEM reconstruction techniques lending insight into their internal structure.