Didemnidines A and B, Indole Spermidine Alkaloids from the New Zealand Ascidian Didemnum sp.

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• 作者：Rhys Finlayson ; A. Norrie Pearce ; Michael J. Page ; Marcel Kaiser ; Marie-Lise Bourguet-Kondracki ; Jacquie L. Harper ; Victoria L. Webb ; Brent R. Copp
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：April 25, 2011
• 年：2011
• 卷：74
• 期：4
• 页码：888-892
• 全文大小：725K
• 年卷期：v.74,no.4(April 25, 2011)
• ISSN：1520-6025

文摘

Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N¹ position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC₅₀'s of 15 and 8.4 渭M, respectively.