Sodium Deoxycholate Hydrogels: Effects of Modifications on Gelation, Drug Release, and Nanotemplating

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• 作者：Kelsey E. McNeel ; Susmita Das ; Noureen Siraj ; Ioan I. Negulescu ; Isiah M. Warner
• 刊名：Journal of Physical Chemistry B
• 出版年：2015
• 出版时间：July 9, 2015
• 年：2015
• 卷：119
• 期：27
• 页码：8651-8659
• 全文大小：400K
• ISSN：1520-5207

文摘

In the present study, sodium deoxycholate (NaDC) was used to produce gelation of tris(hydroxymethyl)amino-methane (TRIS) solutions above, below, and near the pK_a of NaDC, respectively, which yielded a neutral gelator, a charged gelator, and a mixture of each. Impacts of ionic interactions on gel formation were studied in detail and showed that pH can be used to modify many hydrogel properties including sol鈥揼el temperature, crystallinity, and mechanical strength. Several formulations yielded a unique rheological finding of two stable regions of elastic modulus. The release of a small molecule has been investigated under different hydrogel conditions and at variable shear rate, suggesting utility as a drug-delivery vehicle. It was also observed that pH modification of the hydrogels affected nanoparticle formation. Nanoparticles derived from a Group of Uniform Materials Based on Organic Salts (nanoGUMBOS), specifically cyanine-based NIR dyes, were templated within the hydrogel network for potential applications in tissue imaging. These nanoGUMBOS were found to be size-tunable, although material-dependent. Further understanding of NaDC/TRIS gelation has broadened the tunability and multidimensional applications of these tailored hydrogel systems.