Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

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• 作者：Naga K. Modukuru ; Joly Sukumaran ; Steven J. Collier ; Ann Shu Chan ; Anupam Gohel ; Gjalt W. Huisman ; Raquel Keledjian ; Karthik Narayanaswamy ; Scott J. Novick ; S. M. Palanivel ; Derek Smith ; Zhang Wei ; Brian Wong ; Wan Lin Yeo ; David A. Entwistle
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：18
• 期：6
• 页码：810-815
• 全文大小：336K
• 年卷期：v.18,no.6(June 20, 2014)
• ISSN：1520-586X

文摘

This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbazepine).