Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in
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- 作者：Bert Willemsens ; Ivan Vervest ; Dominic Ormerod ; Wim Aelterman ; Christine Fannes ; Narda Mertens ; Istvá ; n E. Markó ; Sebastien Lemaire
- 刊名：Organic Process Research & Development
- 出版年：2006
- 出版时间：November 2006
- 年：2006
- 卷：10
- 期：6
- 页码：1275 - 1281
- 全文大小：344K
- 年卷期：v.10,no.6(November 2006)
- ISSN：1520-586X
文摘
A scalable and safe process for the oxidative rearrangement of
-carboline to quinolone derivatives, intermediates in thesynthesis of PDE-V inhibitors RWJ387273 (R301249) andRWJ444772 (R290629), has been developed.
-carboline to quinolone derivatives, intermediates in thesynthesis of PDE-V inhibitors RWJ387273 (R301249) andRWJ444772 (R290629), has been developed.