Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids

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• 作者：Jonathan Ruchti ; Erick M. Carreira
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2174-2176
• 全文大小：241K
• 年卷期：0
• ISSN：1523-7052

文摘

An enantiospecific approach to the synthesis of optically active, trisubstituted allenes from chiral propargylic benzoates and arylboronic acids has been developed. The transformation is catalyzed by a Rh–(P,olefin) complex formed in situ from [{Rh(cod)Cl}₂] and a readily available phosphoramidite ligand. The method furnishes an assortment of diverse allenes in high yields and excellent enantiospecificity under mild conditions.