Photochemically Induced Folding of Single Chain Polymer Nanoparticles in Water
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- 作者：Carolin Heiler ; Janin T. Offenloch ; Eva Blasco ; Christopher Barner-Kowollik
- 刊名：ACS Macro Letters
- 出版年：2017
- 出版时间：January 17, 2017
- 年：2017
- 卷：6
- 期：1
- 页码：56-61
- 全文大小：477K
- ISSN：2161-1653
文摘
We pioneer the synthesis of fluorescent single chain nanoparticles (SCNPs) via UV-light induced folding based on tetrazole chemistry directly in pure water. Water-soluble photoreactive precursor polymers based on poly(acrylic acid) (PAA) bearing tetrazole, alkene and tetraethylene glycol monomethyl ether moieties, (PAAn(Tet/p-Mal/TEG)), or simply tetrazoles moieties, PAAn(Tet), were generated via RAFT polymerization. While tetrazole, ene, and acrylic acid containing polymers fold via dual nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) as well as nitrile imine-carboxylic acid ligation (NICAL), tetrazole and acrylic acid only functional prepolymers fold exclusively via NICAL. A detailed study of the underpinning photochemistry of NITEC and NICAL is also included. The resulting water-soluble SCNPs were carefully characterized via analytical techniques such as NMR, UV–vis, and fluorescence spectroscopy, as well as SEC and DLS.