Synthesis of Maremycins A and D1 via Cycloaddition of a Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one
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- 作者：Tohru Ueda ; Mitsuhide Inada ; Iwao Okamoto ; Nobuyoshi Morita ; Osamu Tamura
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：May 15, 2008
- 年：2008
- 卷：10
- 期：10
- 页码：2043 - 2046
- 全文大小：123K
- 年卷期：v.10,no.10(May 15, 2008)
- ISSN：1523-7052
文摘
A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with (E)-3-ethylidene-1-methylindolin-2-one as a key step. This synthesis clarifies the stereochemistry of the maremycins and is suitable for large-scale synthesis for biological screening.