One-Pot Approach to 2,3-Disubstituted-2,3-dihydro-4-quinolones from 2-Alkynylbenzamides

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• 作者：Noriko Okamoto ; Kei Takeda ; Minoru Ishikura ; Reiko Yanada
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：76
• 期：21
• 页码：9139-9143
• 全文大小：788K
• 年卷期：v.76,no.21(November 4, 2011)
• ISSN：1520-6904

文摘

Concise and efficient syntheses of various trans-2,3-disubstituted-2,3-dihydro-4-quinolones have been achieved via tandem Hofmann-type rearrangement of 2-alkynylbenzamides, nucleophilic addition of alcohols to the isocyanate intermediates, intermolecular [2+2]-cycloaddition with carbon鈥揷arbon triple bonds and aldehydes, and intramolecular aminocyclization of nitrogen of carbamates to the 伪,尾-unsaturated ketones.