Blueberry Supplementation Improves Memory in Older Adults

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• 作者：Robert Krikorian ; Marcelle D. Shidler ; Tiffany A. Nash ; Wilhelmina Kalt ; Melinda R. Vinqvist-Tymchuk ; Barbara Shukitt-Hale ; James A. Joseph
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2010
• 出版时间：April 14, 2010
• 年：2010
• 卷：58
• 期：7
• 页码：3996-4000
• 全文大小：688K
• 年卷期：v.58,no.7(April 14, 2010)
• ISSN：1520-5118

文摘

The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to address this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers, mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration. This study investigated the effects of daily consumption of wild blueberry juice in a sample of nine older adults with early memory changes. At 12 weeks, improved paired associate learning (p = 0.009) and word list recall (p = 0.04) were observed. In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.