Toward an Image-Guided Microbeam Radiation Therapy Using Gadolinium-Based Nanoparticles

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• 作者：Géraldine Le Duc ; Imen Miladi ; Christophe Alric ; Pierre Mowat ; Elke Bräuer-Krisch ; Audrey Bouchet ; Enam Khalil ; Claire Billotey ; Marc Janier ; François Lux ; Thierry Epicier ; Pascal Perriat ; Stéphane Roux ; Olivier Tillement
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：December 27, 2011
• 年：2011
• 卷：5
• 期：12
• 页码：9566-9574
• 全文大小：1029K
• 年卷期：0
• ISSN：1936-086X

文摘

Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for magnetic resonance imaging and a radiosentizing effect. The exploitation of these characteristics leads to a greater increase in lifespan of rats bearing brain tumors since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is, at the same time, sufficiently high in the tumor and low in the surrounding healthy tissue. GBNs exhibit therefore an interesting potential for image-guided radiotherapy.