Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with 纬-Cyclodextrin

详细信息    查看全文

• 作者：Yukiko Uekaji ; Mayu Onishi ; Daisuke Nakata ; Keiji Terao ; Arja Paananen ; Riitta Partanen ; Hidefumi Yoshii
• 刊名：Journal of Physical Chemistry B
• 出版年：2014
• 出版时间：October 2, 2014
• 年：2014
• 卷：118
• 期：39
• 页码：11480-11486
• 全文大小：428K
• ISSN：1520-5207

文摘

Micelles can be formed from coenzyme Q₁₀ (CoQ₁₀) and dipotassium glycyrrhizate (GZK₂) by using an inclusion complex of CoQ₁₀ with 纬-cyclodextrin (纬-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK₂ to a supersaturated solution of the CoQ₁₀/纬-CD inclusion complex led to a linear increase in the solubility of CoQ₁₀ due to the formation of micelles of CoQ₁₀ when the molar ratio of GZK₂/纬-CD increased to 鈭?.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (鈭? and the ratio of GZK₂ to CoQ₁₀ was 1. These results suggest that the formation of CoQ₁₀ micelles with GZK₂ might proceed via the displacement of CoQ₁₀ by GZK₂ in the 纬-CD cavity followed by the formation of CoQ₁₀ micelles.