Tandem Dienone Photorearrangement鈥揅ycloaddition for the Rapid Generation of Molecular Complexity
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- 作者：Pieter H. Bos ; Mitchell T. Antalek ; John A. Porco ; Jr. ; Corey R. J. Stephenson
- 刊名：Journal of the American Chemical Society
- 出版年：2013
- 出版时间：November 27, 2013
- 年：2013
- 卷：135
- 期：47
- 页码：17978-17982
- 全文大小：424K
- 年卷期：v.135,no.47(November 27, 2013)
- ISSN：1520-5126
文摘
A tandem dienone photorearrangement鈥揷ycloaddition (DPC) reaction of novel cyclohexadienone substrates tethered with various 2蟺 and 4蟺 reaction partners resulted in the formation of polycyclic, bridged frameworks. In particular, use of alkynyl ether-tethered substrates led to (3 + 2) cycloaddition to afford strained alkenes which could be further elaborated by intra- and intermolecular cycloaddition chemistry to produce complex, polycyclic chemotypes.