Eucapsitrione, an Anti-Mycobacterium tuberculosis Anthraquinone Derivative from the Cultured Freshwater Cyanobacterium Eucapsis sp.
详细信息 查看全文
- 作者：Megan Sturdy ; Aleksej Krunic ; Sanghyun Cho ; Scott Franzblau ; Jimmy Orjala
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：August 27, 2010
- 年：2010
- 卷：73
- 期：8
- 页码：1441-1443
- 全文大小：121K
- 年卷期：v.73,no.8(August 27, 2010)
- ISSN：1520-6025
文摘
Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 μM, respectively.