Construction of a Well-Defined Multifunctional Dendrimer for Theranostics

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• 作者：Ca虂tia Ornelas ; Ryan Pennell ; Leonard F. Liebes ; Marcus Weck
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：976-979
• 全文大小：778K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty-four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described here might be promising for fabricating the next generation of materials for theranostics.