Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS03-21
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- 作者：Hui Wang ; Yi Wang ; Wei Wang ; Peng Fu ; Peipei Liu ; Weiming Zhu
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：September 23, 2011
- 年：2011
- 卷：74
- 期：9
- 页码：2014-2018
- 全文大小：710K
- 年卷期：v.74,no.9(September 23, 2011)
- ISSN：1520-6025
文摘
Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A鈥揅 (1鈥?b>3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (鈭?-mitorubrin (8), and orsellinic acid. The structures of 1鈥?b>6 were elucidated primarily by NMR experiments. The absolute configurations of 1鈥?b>4 were assigned on the basis of CD and NOESY data. Compounds 2鈥?b>4 and 7 exhibited significant antiviral activity against H1N1, with IC50 values of 61.3, 64.0, 85.3, and 58.6 渭M, respectively.