Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

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• 作者：Shinichiro Okamoto ; Arihiro Iwasaki ; Osamu Ohno ; Kiyotake Suenaga
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2719-2725
• 全文大小：303K
• ISSN：1520-6025

文摘

Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC₅₀ values of 8.1 and 9.0 渭M, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.