Isoflavonoids Isolated from Cuban Propolis

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• 作者：Anna Lisa Piccinelli ; Mercedes Campo Fernandez ; Osmany Cuesta-Rubio ; Ingrid Má ; rquez Herná ; ndez ; Francesco De Simone ; and Luca Rastrelli
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：November 16, 2005
• 年：2005
• 卷：53
• 期：23
• 页码：9010 - 9016
• 全文大小：114K
• 年卷期：v.53,no.23(November 16, 2005)
• ISSN：1520-5118

文摘

Chemical investigation of a red-type Cuban propolis sample has led to the isolation of 11 isoflavonoids(2 isoflavones, 3 isoflavans, and 6 pterocarpans), together with gallic acid, isoliquiritigenin, and (-)-liquiritigenin. Structural determination, including the absolute stereochemistry, was accomplished byspectroscopic analysis, particularly CD and 2D NMR techniques. The fragmentation behavior ofpterocarpans was studied by electrospray ionization (ESI) tandem mass spectrometry (MS/MS) usingan ion-trap analyzer, and a generalized fragmentation pathway, useful in the identification and structuralcharacterization of pterocarpans, is proposed. Isoflavonoids are reported for the first time from propolissamples.Keywords: Propolis; isoflavonoids; isoflavans; pterocarpans; isoliquiritigenin; (-)-liquiritigenin; 1Dand 2D NMR spectroscopy; CD; ESI-MS/MS