Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction
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- 作者：Timothy D. Gross ; Shine Chou ; Daniel Bonneville ; Raymond S. Gross ; Peng Wang ; Onorato Campopiano ; Michael A. Ouellette ; Scott E. Zook ; Jayachandra P. Reddy ; Wilna J. Moree ; Florence Jovic ; Shubham Chop
- 刊名：Organic Process Research & Development
- 出版年：2008
- 出版时间：September 19, 2008
- 年：2008
- 卷：12
- 期：5
- 页码：929-939
- 全文大小：248K
- 年卷期：v.12,no.5(September 19, 2008)
- ISSN：1520-586X
文摘
The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.