An Approach to Early-Phase Salt Selection: Application to NBI-75043
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- 作者：Timothy D. Gross ; Kevin Schaab ; Michael Ouellette ; Scott Zook ; Jayachandra P. Reddy ; Arthur Shurtleff ; Aida I. Sacaan ; Tanja Alebic-Kolbah ; Haig Bozigian
- 刊名：Organic Process Research & Development
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：11
- 期：3
- 页码：365 - 377
- 全文大小：1508K
- 年卷期：v.11,no.3(May 2007)
- ISSN：1520-586X
文摘
A strategy for the salt selection of NBI-75043 is presented andsummarized in a decision-tree format. This is followed by thefirst scale-up of the process, confirmation of a new polymorph,and description of a method for its conversion to the initialform.