Overcoming Regioselectivity Issues Inherent in Bis-Tröger's Base Preparation

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• 作者：Martin Havlí ; k ; Vladimí ; r Krá ; l ; Bohumil Dolensk//pubs.acs.org/images/entities/yacute.gif" border="0">
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：October 12, 2006
• 年：2006
• 卷：8
• 期：21
• 页码：4867 - 4870
• 全文大小：148K
• 年卷期：v.8,no.21(October 12, 2006)
• ISSN：1523-7052

文摘

<TR>Bis-Tr&ouml;ger's base derivatives are a new family of molecular tweezers. A major drawback to their study is a lack of commercially availableprecursors, ortho-nitrocarboxylic acids. A reverse synthetic strategy starting from known dinitrodicarboxylic acids, which circumvents thisproblem, is presented. Via this methodology regioisomeric bis-TB derivatives can be prepared selectively, using only common aromatic aminesthat are typically commercially available.