Enantioselective Synthesis of Cephalimysins B and C

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• 作者：David Chalupa ; Petra Vojáčková ; Jiří Partl ; Dražen Pavlović ; Marek Nečas ; Jakub Švenda
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：750-753
• 全文大小：411K
• ISSN：1523-7052

文摘

The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)–diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation–lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.